Development of an electronic system based on electrochemical sensors and biosensors for the control of biogenic amines
PROJECT WORK PLAN (2012 - 2015)
Year | Objectives | Activities | Results to be delivered |
2012 | 1. Modeling and simulating studies of interaction between biogenic amine compounds and receptor element of sensors and biosensors. | 1.1. Modeling of interaction mechanism between biogenic amines and receptor element of sensors in absence and applying a potential |
Publication of minimum 2 ISI papers
Participation to at least 3 scientific
conferences
|
1.2. Modeling of interaction mechanism between biogenic amines and receptor element of biosensors in absence and applying a potential | |||
1.3. Simulation of chemical species dynamics at the surface of sensors and biosensors | |||
1.4. Theoretical study about the influence of some parameters (pH, temperature) on the biosensor response | |||
2. Selection of sensors and biosensors designs | 2.1. Study of commercial sensors designs | ||
2.2. Design of novel sensors | |||
2.3. Use of voltammetry and potentiometry in measurements of sensors and biosensors responses | |||
3. Improvement of sensors qualities and design of novel sensors and biosensors | 3.1. Synthesis and characterization of molecular materials | ||
3.2. Synthesis and characterization of conducting polymers | |||
3.3. Fabrication of novel sensors and biosensors: selection of the substrates, selection and application of deposition methods, immobilization of enzymes onto electrodes | |||
3.4. Characterization of sensors and biosensors by spectroscopic (UV-Vis, NIR and IR) and microscopic (SEM, BAM and AFM) techniques |
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2013 | 1. Fundamental studies of the interaction between sensitive layer and samples under study | 1.1. Study of interactions between biogenic amines and active layer of sensors |
Publication of minimum 2 ISI papers
Participation to at least 3 scientific
conferences
|
1.2. Study of interactions between biogenic amines and active layer of biosensors | |||
1.3. Study of enzyme kinetics of biosensors | |||
1.4. Comparison of experimental data with those obtained in modeling and simulation studies | |||
2. Data treatment and interpretation of the results | 2.1 Establishment of methods for data analysis. Exploratory analysis | ||
2.2 Pre-processing of experimental data | |||
2.3 Application of Principal Component Analysis method for processing of experimental data | |||
2.4 Application of classification methods (PLS-DA and SIMCA) for processing of experimental data | |||
2.5 Establishment of correlations between sensors and biosensors signals and the results of physico-chemical analysis or sensory |
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2014 | 1. Test of the sensing capabilities of the sensors and biosensors | 1.1. Study of the selectivity of sensors and biosensors |
Publication of minimum 2 ISI papers
Participation to at least
2 scientific
conferences
|
1.2. Study of the stability of sensors and biosensors | |||
1.3. Study of the reproducibility of sensors and biosensors | |||
1.4. Study of the lifetime of sensors and biosensors | |||
1.5. Determination of the detection limits of sensors and biosensors | |||
1.6. Determination of the response time of sensors and biosensors | |||
1.7. Determination of the reversibility and the recovery of sensors and biosensors | |||
2015 | 1. Test of sensors and biosensors in real samples. Applicative studies | 1.1. Selecting of sensors and biosensors arrays for applications in real samples |
Publication of minimum 2 ISI papers
Participation to at least
2 scientific
conferences
|
1.2. Selection of the methods for data treatment | |||
1.3. Analysis of biogenic amines in meat products, cheeses and fermented beverages | |||
2016 | 1. Test of sensors and biosensors in real samples. Applicative studies | 1.4. Monitoring of food freshness |
Publication of minimum 2 ISI papers
Participation to at least
2 scientific
conferences
|
1.5. Analysis of biogenic amines in fruits |
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1.6. Analysis of biogenic amines in clinical samples | |||
1.7. Validation of the systems by the establishment of correlations between the results obtained with sensors and biosensors and the results of physico-chemical, sensory, biochemical and medical analyses |
Copyright © 2012–2016